Sildigra, a popular brand of sildenafil citrate is a drug used mainly for the treatment of the erectile dysfunction in men. Erectile dysfunction (ED) commonly known as impotence, a sexual disability in which a man is unable of obtaining or holding an erection during sexual intercourse. Because of the purpose of this drug, this has been studied with men affected by erectile dysfunction. According to the studies, Sildigra has been proven to benefit men with ED participate in sexual activity.
Mechanism Of Action
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.
Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the
corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.
How to take the medicine
However, the medication may be taken any time from 4 hours to half an hour before sexual activity.
Sildenafil may be taken with or without food, but taking it with a high-fat meal may increase the time before the medication starts working.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications.
It is important to take this medication exactly as prescribed by your doctor. Do not take higher doses of this medication than those prescribed by your doctor. Contact your doctor if you take a greater dose of sildenafil than prescribed.
Store this medication in its original package at room temperature, protect it from moisture, and keep it out of the reach of children.
Do not take sildenafil if you:
are allergic to sildenafil or any ingredients of this medication
are taking any type of nitrate medication in any form (oral, sublingual, skin patch, or spray). Nitrate medications include nitroglycerin and related medications that are used for the relief of chest pain or angina. Use of these medications with sildenafil could cause a sudden severe drop in blood pressure that could lead to dizziness, fainting, heart attack, or stroke.
have been advised by your doctor not to engage in sexual activity
have a history of vision problems related to nerve damage to the retina caused by decreased blood flow
Important safety information:
Sildenafil may cause drowsiness, dizziness, fainting, or blurred vision. These effects may be worse if you use it with alcohol or certain medicines. Use sildenafil with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Sildenafil may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
Patients with heart problems who use sildenafil may be at increased risk of heart-related side effects, including a heart attack or stroke. Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting. Contact your doctor or seek medical attention right away if you experience these symptoms.
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