Sildigra 25mg is a productive and strong medication viable in dealing with the issue of Erectile Dysfunction. It contains a functioning part of Sildenafil citrate with 25mg salt. The manufacturing of the medication is done for RSM Enterprises. It helps an individual with accomplishing or support an erection needed for erotic procedures. The dynamic segment of the medication has a place with a class of PDE5 inhibitor compound. It elevates unwinding to the veins giving a further developed progression of blood in the penile area. With an addition in erotic potential, the medication capacities only with exotic incitement, upgrading penile capacity. It oversees sensual tangles like ED in a brief period with capable and dynamic outcomes.
Description of the Sildenafil 25mg:
The Sildenafil Citrate 25mg is formulated as white, film-coated round tablets for oral consumption.
People over 65 years old as well as anyone with kidney or liver impairment should start with a dose of 25 mg.
For those taking ritonavir (Norvir), and other medications to treat HIV, the recommended dose is 25 mg before sexual activity, and the maximum dose is 25 mg within a 48-hour period.
Those taking CYP3A4 inhibitors such as ketonconazole (Xolegel, Extina, Nizoral), itraconazole (Onmel, Sporanox), or erythromycin (Akne-mycin, Staticin), should start with a 25 mg dose.
Mechanism Of Action:
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.Sildigra (sildenafil) enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildigra (sildenafil) causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildigra (sildenafil) at recommended doses has no effect in the absence of sexual stimulation.
How to take the medicine:
The usual recommended dose is 100 mg taken as needed, approximately 30 to 60 minutes before sexual activity. However, the medication may be taken any time from 4 hours to half an hour before sexual activity.
Sildenafil may be taken with or without food, but taking it with a high-fat meal may increase the time before the medication starts working.
Sildigra 25mg is recommended for those above the age of 55 years having any cardiac dieses , kindney issues or liver problem. However,physician consultation is mandatory.
Do not take sildigra 25mg if you:
Are allergic to sildenafil citrate or if you have been advised by your doctor not to engage in sexual activity.
Precautions of Sildigra 25mg:
Do not take Sildigra 25mg, if anyone has hypersensitivities or taking any kind of nitroglycerin or the people who have had a heart attack, stroke, genuine high or low circulatory strain or unsafe heart irregularities. This prescription doesn’t guarantee against explicitly transmitted contaminations, (for instance, HIV, hepatitis B, gonorrhea, syphilis). Keep in mind; it isn’t for individuals with conditions, for instance, sickle cell iron issue, different myeloma or leukemia. Search for therapeutic direction with genital distortions, for instance, Peyronie’s disease; in like manner, if you have a draining issue, peptic ulcer, or retinitis pigmentosa.
Side effects of Sildigra 25mg: