Sildigra, a popular brand of sildenafil citrate is a drug used mainly for the treatment of the erectile dysfunction in men. Erectile dysfunction (ED) commonly known as impotence, a sexual disability in which a man is unable of obtaining or holding an erection during sexual intercourse. Because of the purpose of this drug, this has been studied with men affected by erectile dysfunction. According to the studies, Sildigra has been proven to benefit men with ED participate in sexual activity.
Analysis on Sildenafil confirm that men with ED treated with sildenafil 100 mg, compared with those treated with sildenafil 50 mg, may be more likely to achieve a greater improvement in erectile function with little or no greater risk to overall tolerability during the first 2 weeks of treatment, completely hard and fully rigid erections.
Mechanism Of Action Sildigra 100mg:
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in thecorpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.
How to take Sildigra 100mg:
The usual recommended dose is 50 mg taken as needed, approximately 30 to 60 minutes before sexual activity. However, the medication may be taken any time from 4 hours to half an hour before sexual activity.
Sildenafil may be taken with or without food, but taking it with a high-fat meal may increase the time before the medication starts working.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications.
Do not take sildenafil if you:
are allergic to sildenafil or any ingredients of this medication
are taking any type of nitrate medication in any form (oral, sublingual, skin patch, or spray). Nitrate medications include nitroglycerin and related medications that are used for the relief of chest pain or angina. Use of these medications with sildenafil could cause a sudden severe drop in blood pressure that could lead to dizziness, fainting, heart attack, or stroke.
have been advised by your doctor not to engage in sexual activity
have a history of vision problems related to nerve damage to the retina caused by decreased blood flow
Stop using sildenafil and call your doctor at once if you have a serious side effect such as:
sudden vision loss;
ringing in your ears, or sudden hearing loss;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
swelling in your hands, ankles, or feet;
shortness of breath;
feeling light-headed, fainting; or
penis erection that is painful or lasts 4 hours or longer.
Less serious side effects may include:
warmth or redness in your face, neck, or chest;
Sildigra 100mg Precautions:
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Consumption of alcohol in large amounts may decrease the ability to get an erection and may also temporarily decrease blood pressure, causing dizziness and fainting.
Tell your doctor if you are taking medications to treat high blood pressure. The combination of these medications and sildenafil may add to the blood pressure-lowering effect of these medications. You should also let your doctor know if you have or have had low blood pressure.
Some MEDICINES MAY INTERACT with sildenafil. Tell your health care provider if you are taking any other medicines, especially any of the following:
Alpha-blockers (eg, doxazosin), medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, light-headedness, and fainting may occur
Azole antifungals (eg, itraconazole, ketoconazole), H2 antagonists (eg, cimetidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), or telithromycin because they may increase the risk of sildenafil's side effects
Barbiturates (eg, phenobarbital), bosentan, carbamazepine, efavirenz, nevirapine, phenytoin, rifabutin, or rifampin because they may decrease sildenafil's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if sildenafil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Order Sildenafil Online at alldaypill.com