Sildigra, a popular brand of sildenafil citrate is a drug used mainly for the treatment of the Erectile Dysfunction in men. Erectile Dysfunction (ED) commonly known as impotency, is a sexual disability in which a man is unable to obtain or hold an erection during sexual intercourse. Because of the purpose of this drug, this has been studied with men affected by erectile dysfunction. According to the studies, Sildigra has been proven to benefit men with ED and help to actively participate in sexual activity..
Description of the Sildenafil 25mg :-
The Sildenafil Citrate 25mg is formulated as white, film-coated round tablets for oral consumption.
People over 65 years old as well as anyone with kidney or liver impairment should start with a dose of 25 mg.
For those taking ritonavir (Norvir), and other medications to treat HIV, the recommended dose is 25 mg before sexual activity, and the maximum dose is 25 mg within a 48-hour period.
Those taking CYP3A4 inhibitors such as ketonconazole (Xolegel, Extina, Nizoral), itraconazole (Onmel, Sporanox), or erythromycin (Akne-mycin, Staticin), should start with a 25 mg dose.
Mechanism Of Action
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.Sildigra (sildenafil) enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildigra (sildenafil) causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildigra (sildenafil) at recommended doses has no effect in the absence of sexual stimulation.
How to take the medicine
The usual recommended dose is 100 mg taken as needed, approximately 30 to 60 minutes before sexual activity. However, the medication may be taken any time from 4 hours to half an hour before sexual activity.
Sildenafil may be taken with or without food, but taking it with a high-fat meal may increase the time before the medication starts working.
Sildigra 25mg is recommended for those above the age of 55 years having any cardiac dieses , kindney issues or liver problem. However,physician consultation is mandatory.
Do not take sildigra 25mg if you:
- Are allergic to sildenafil citrate or if you have been advised by your doctor not to engage in sexual activity.
|Generic Name||Sildenafil Citrate|